r\u00e9sultats de l’\u00e9tude.<\/a> <\/p>\n[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ custom_padding_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb admin_label=\u00a0\u00bbSection\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#f8f8f8″ custom_padding=\u00a0\u00bb100px|20px|100px|20px|true|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb60px||60px||true|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb40px||40px||true|false\u00a0\u00bb da_disable_devices=\u00a0\u00bboff|off|off\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb da_is_popup=\u00a0\u00bboff\u00a0\u00bb da_exit_intent=\u00a0\u00bboff\u00a0\u00bb da_has_close=\u00a0\u00bbon\u00a0\u00bb da_alt_close=\u00a0\u00bboff\u00a0\u00bb da_dark_close=\u00a0\u00bboff\u00a0\u00bb da_not_modal=\u00a0\u00bbon\u00a0\u00bb da_is_singular=\u00a0\u00bboff\u00a0\u00bb da_with_loader=\u00a0\u00bboff\u00a0\u00bb da_has_shadow=\u00a0\u00bbon\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px||true|true\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_heading title=\u00a0\u00bbProjets r\u00e9compens\u00e9s\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb title_level=\u00a0\u00bbh2″ title_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb title_text_color=\u00a0\u00bb#009ee6″ title_font_size=\u00a0\u00bb22px\u00a0\u00bb title_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||40px||false|false\u00a0\u00bb title_font_size_tablet=\u00a0\u00bb30px\u00a0\u00bb title_font_size_phone=\u00a0\u00bb26px\u00a0\u00bb title_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb0px||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbEffet de la s\u00e9dation volatile sur la respiration spontan\u00e9e pendant la ventilation m\u00e9canique chez les patients atteints du syndrome de d\u00e9tresse respiratoire aigu\u00eb\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2021<\/p>\n
Luigi Camporota, MD PhD & Guy William Glover, MBChB FRCA FFICM DICM<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Luigi-Camporota.jpg\u00a0\u00bb alt=\u00a0\u00bbLuigi Camporota\u00a0\u00bb title_text=\u00a0\u00bbLuigi-Camporota\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
L’\u00e9tude vise \u00e0 comparer les effets de la s\u00e9dation inhal\u00e9e \u00e0 l’isoflurane administr\u00e9e par le DAA Sedaconda \u00e0 ceux de la s\u00e9dation intraveineuse chez les patients atteints du syndrome de d\u00e9tresse respiratoire aigu\u00eb (SDRA).<\/p>\n
Les principaux r\u00e9sultats comprennent la commande respiratoire, l’effort inspiratoire, les \u00e9changes gazeux et l’efficacit\u00e9 de la ventilation au cours de la ventilation assist\u00e9e par pression (VASP) dans le SDRA. Des r\u00e9sultats suppl\u00e9mentaires \u00e9valueront la pharmacocin\u00e9tique de l’administration de s\u00e9datifs inhal\u00e9s en fonction de la ventilation minute, de la ventilation de l’espace mort, de l’\u00e9limination du CO22 et du volume pulmonaire. <\/p>\n
L’\u00e9tude portera sur des patients adultes atteints de SDRA, recevant une VSP invasive et s\u00e9dat\u00e9s par analgo-s\u00e9dation IV, qui devraient rester sous VSP avec une \u00e9chelle d’agitation et de s\u00e9dation de Richmond (RASS) stable pendant 24 heures ou plus. Pendant 6 heures, les patients recevront une s\u00e9dation inhal\u00e9e titr\u00e9e \u00e0 une RASS \u00e9quivalente et seront compar\u00e9s, dans un essai crois\u00e9, \u00e0 la s\u00e9dation IV standard (propofol et fentanyl). La s\u00e9dation inhal\u00e9e peut conduire \u00e0 un plus grand degr\u00e9 de respiration spontan\u00e9e. Il sera important de comprendre son impact sur la commande et l’effort respiratoires dans le SDRA, car ceux-ci peuvent varier en fonction de la dose de s\u00e9datif inhal\u00e9 et de la profondeur de la s\u00e9dation, ainsi que des caract\u00e9ristiques physiologiques et m\u00e9caniques du poumon. <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbEffets du s\u00e9voflurane sur l'eau pulmonaire extravasculaire et la perm\u00e9abilit\u00e9 vasculaire pulmonaire chez les patients atteints du syndrome de d\u00e9tresse respiratoire aigu\u00eb.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2020<\/p>\n
Dr Christopher Lai, MD, Professeur Xavier Monnet, MD, T\u00e0i Pham, MD PhD.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Dr-Christopher-Lai.jpg\u00a0\u00bb alt=\u00a0\u00bbDr Christopher Lai\u00a0\u00bb title_text=\u00a0\u00bbDr-Christopher-Lai\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Les patients atteints de SDRA et trait\u00e9s au s\u00e9voflurane pr\u00e9sentent une r\u00e9duction de la r\u00e9ponse inflammatoire pulmonaire et une am\u00e9lioration de l’oxyg\u00e9nation. Des \u00e9tudes pr\u00e9cliniques sur la s\u00e9dation inhal\u00e9e dans le SDRA exp\u00e9rimental ont montr\u00e9 une r\u00e9duction de l’\u0153d\u00e8me pulmonaire, mais cela n’a pas \u00e9t\u00e9 \u00e9tudi\u00e9 chez l’homme. <\/p>\n
Dans cette \u00e9tude, l’hypoth\u00e8se est que le m\u00e9canisme \u00e0 l’origine de l’am\u00e9lioration de l’oxyg\u00e9nation par le s\u00e9voflurane dans le SDRA est la r\u00e9duction de l’\u0153d\u00e8me pulmonaire.<\/p>\n
Ce projet de recherche \u00e9valuera les effets de la s\u00e9dation inhal\u00e9e via l’AnaConDa, par rapport au propofol, sur l’indice d’eau pulmonaire extravasculaire (EVLWi) et l’indice de perm\u00e9abilit\u00e9 vasculaire pulmonaire (PVPI) chez les patients atteints de SDRA. L’objectif de l’\u00e9tude est de mieux comprendre les effets protecteurs de la s\u00e9dation inhal\u00e9e sur les poumons dans le SDRA. <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbS\u00e9dation volatile de courte dur\u00e9e chez les patients subissant une chirurgie valvulaire cardiaque : un essai prospectif randomis\u00e9 et contr\u00f4l\u00e9.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2020<\/p>\n
Armin Flinspach, MD, Elisabeth Adam, MD.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Armin-Flinspach.jpg\u00a0\u00bb title_text=\u00a0\u00bbArmin-Flinspach\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Apr\u00e8s une chirurgie cardiaque, des s\u00e9datifs sont syst\u00e9matiquement administr\u00e9s dans l’unit\u00e9 de soins intensifs (USI) pour faciliter la ventilation m\u00e9canique. En raison de l’\u00e2ge avanc\u00e9 des patients ayant subi une chirurgie cardiaque complexe, avec une pr\u00e9valence croissante de dysfonctionnements h\u00e9patiques et r\u00e9naux, le m\u00e9tabolisme des s\u00e9datifs intraveineux est en partie gravement alt\u00e9r\u00e9 et peut conduire \u00e0 une surs\u00e9dation, une ventilation m\u00e9canique prolong\u00e9e, un d\u00e9lire et une hypotension induite par les m\u00e9dicaments. <\/p>\n
De plus en plus de donn\u00e9es indiquent que la s\u00e9dation volatile favorise un r\u00e9veil plus rapide des patients et des temps d’extubation plus courts dans le cadre des soins intensifs chirurgicaux. En particulier, la chirurgie valvulaire (multiple) n\u00e9cessitant une intervention prolong\u00e9e et le temps pass\u00e9 sur le pontage cardiopulmonaire sont diff\u00e9rents de ceux de la chirurgie de pontage aorto-coronarien. Ces variables peuvent conduire \u00e0 des r\u00e9sultats diff\u00e9rents de ceux observ\u00e9s chez les patients ayant subi un pontage aorto-coronarien. <\/p>\n
L’objectif de l’\u00e9tude est de d\u00e9terminer si les patients subissant une chirurgie valvulaire cardiaque b\u00e9n\u00e9ficieront de l’administration postop\u00e9ratoire d’anesth\u00e9siques volatils.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbDispositif AnaConDa en chirurgie cardiaque : une solution simple pour r\u00e9aliser une anesth\u00e9sie totale par inhalation avec le s\u00e9voflurane.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2020<\/p>\n
Francois Labaste, MD, Professeur Vincent Miniville, Professeur Bertrand Marcheix.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Francois-Labaste-MD.jpg\u00a0\u00bb alt=\u00a0\u00bbFran\u00e7ois Labaste\u00a0\u00bb title_text=\u00a0\u00bbFrancois-Labaste-MD\u00a0\u00bb align=\u00a0\u00bbcenter\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_height=\u00a0\u00bb550px\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Les agents anesth\u00e9siques volatils (inhal\u00e9s) ont des effets cardioprotecteurs. Leur administration avant un \u00e9pisode d’isch\u00e9mie cardiaque prolong\u00e9e est connue sous le nom de pr\u00e9conditionnement anesth\u00e9sique. <\/p>\n
Plusieurs \u00e9tudes cliniques indiquent que les anesth\u00e9siques volatils administr\u00e9s pendant la chirurgie cardiaque conf\u00e8rent une protection myocardique et r\u00e9duisent le risque d’infarctus du myocarde p\u00e9riop\u00e9ratoire, de dysfonctionnement myocardique et de d\u00e9c\u00e8s. D’autres essais randomis\u00e9s n’ont pas confirm\u00e9 le b\u00e9n\u00e9fice des anesth\u00e9siques volatils sur la mortalit\u00e9 \u00e0 long terme, mais dans ces essais, les anesth\u00e9siques inhal\u00e9s n’\u00e9taient pas administr\u00e9s pendant le pontage cardio-pulmonaire (CPB) en raison de l’absence de m\u00e9thodes de vaporisation pendant le CPB. <\/p>\n
L’\u00e9quipe de recherche a trouv\u00e9 et mis en \u0153uvre avec succ\u00e8s une m\u00e9thode pour administrer des anesth\u00e9siques inhal\u00e9s via l’AnaConDa pendant la CPB, permettant une anesth\u00e9sie inhal\u00e9e totale pendant toute la dur\u00e9e de l’intervention chirurgicale.<\/p>\n
L’objectif principal de l’\u00e9tude, qui compare l’anesth\u00e9sie totale par inhalation et la s\u00e9dation postop\u00e9ratoire \u00e0 l’anesth\u00e9sie et \u00e0 la s\u00e9dation par voie intraveineuse, est de d\u00e9crire la faisabilit\u00e9 et la s\u00e9curit\u00e9 de l’utilisation de l’AnaConDa au cours de la chirurgie cardiaque avec CPB.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbFaisabilit\u00e9 et s\u00e9curit\u00e9 de la s\u00e9dation inhal\u00e9e chez les patients ECMO soumis \u00e0 une ventilation ultra-protectrice \u00e0 basse fr\u00e9quence.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2019<\/p>\n
Dr Giuseppe Foti, professeur associ\u00e9 et directeur, et Dr Marco Giani.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Dr-Giuseppe-Foti.jpg\u00a0\u00bb alt=\u00a0\u00bbDr Giuseppe Foti\u00a0\u00bb title_text=\u00a0\u00bbDr-Giuseppe-Foti\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Cette \u00e9tude portera sur la s\u00e9dation inhal\u00e9e administr\u00e9e avec l’AnaConDa chez des patients atteints du syndrome de d\u00e9tresse respiratoire aigu\u00eb (SDRA) soumis \u00e0 une oxyg\u00e9nation par membrane extracorporelle veino-veineuse avec des volumes courants ultra-protecteurs et une ventilation \u00e0 basse fr\u00e9quence.<\/p>\n
Les patients sous oxyg\u00e9nation par membrane extracorporelle (ECMO) recevront une s\u00e9dation intraveineuse et une s\u00e9dation inhal\u00e9e avec du s\u00e9voflurane dans un ordre al\u00e9atoire.<\/p>\n
La faisabilit\u00e9 de la s\u00e9dation et la compensation de la s\u00e9dation seront compar\u00e9es entre les strat\u00e9gies de s\u00e9dation. Si les donn\u00e9es r\u00e9trospectives sont prometteuses, une \u00e9tude prospective confirmerait que les anesth\u00e9siques inhal\u00e9s, qui semblent prot\u00e9ger les poumons, peuvent \u00eatre utilis\u00e9s chez des patients normalement consid\u00e9r\u00e9s comme trop malades pour \u00eatre absorb\u00e9s et \u00e9limin\u00e9s par les poumons. <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbEffets des anesth\u00e9siques inhal\u00e9s sur la pression art\u00e9rielle pulmonaire moyenne chez les patients atteints de SDRA.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2019<\/p>\n
Dr Gabriel Parzy, Dr Jean-Marie Forel et Dr Laurent Papazian<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||20px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||50px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb border_style_bottom=\u00a0\u00bbsolid\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Dr-Gabriel-Parzy.jpg\u00a0\u00bb alt=\u00a0\u00bbDr Gabriel Parzy\u00a0\u00bb title_text=\u00a0\u00bbDr-Gabriel-Parzy\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
L’objectif principal de ce projet de recherche est d’\u00e9tudier la r\u00e9duction potentielle de la pression art\u00e9rielle pulmonaire moyenne (PAPm) pendant la s\u00e9dation inhal\u00e9e via l’AnaConDa, chez les patients atteints de SDRA mod\u00e9r\u00e9 ou s\u00e9v\u00e8re.<\/p>\n
Le SDRA est associ\u00e9 \u00e0 des complications cardio-pulmonaires, dont le c\u0153ur pulmonaire, et pr\u00e9sente un taux de mortalit\u00e9 \u00e9lev\u00e9. Bien que les anesth\u00e9siques inhal\u00e9s soient connus pour \u00eatre vasodilatateurs en g\u00e9n\u00e9ral, leurs effets potentiels sur le SDRA n’ont pas \u00e9t\u00e9 bien \u00e9tudi\u00e9s jusqu’\u00e0 pr\u00e9sent. <\/p>\n
Les patients atteints de SDRA sous ventilation m\u00e9canique recevront du s\u00e9voflurane et la PAPm sera mesur\u00e9e avant et une heure apr\u00e8s l’introduction d’une faible dose de s\u00e9voflurane. La r\u00e9duction des pressions pulmonaires \u00e0 l’aide d’anesth\u00e9siques inhal\u00e9s peut potentiellement am\u00e9liorer les r\u00e9sultats chez les patients atteints de SDRA. <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||||false|false\u00a0\u00bb module_alignment_tablet=\u00a0\u00bb\u00a0\u00bb module_alignment_phone=\u00a0\u00bbcenter\u00a0\u00bb module_alignment_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_blurb title=\u00a0\u00bbS\u00e9dation au s\u00e9voflurane chez les patients atteints du SDRA COVID-19 pour r\u00e9duire les l\u00e9sions pulmonaires : un essai contr\u00f4l\u00e9 randomis\u00e9.\u00a0\u00bb content_max_width=\u00a0\u00bb100%\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_level=\u00a0\u00bbh3″ header_font=\u00a0\u00bb–et_global_heading_font|||on|||||\u00a0\u00bb header_text_align=\u00a0\u00bbleft\u00a0\u00bb header_text_color=\u00a0\u00bbgcid-primary-color\u00a0\u00bb header_font_size=\u00a0\u00bb21px\u00a0\u00bb header_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb header_line_height=\u00a0\u00bb1.4em\u00a0\u00bb body_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb body_text_color=\u00a0\u00bb#666666″ body_font_size=\u00a0\u00bb16px\u00a0\u00bb body_line_height=\u00a0\u00bb26px\u00a0\u00bb custom_padding=\u00a0\u00bb|||20px|false|false\u00a0\u00bb header_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb header_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_font_size_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb border_width_left=\u00a0\u00bb2px\u00a0\u00bb border_color_left=\u00a0\u00bbgcid-secondary-color\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-primary-color%22:%91%22header_text_color%22,%22header_text_color%22%93,%22gcid-secondary-color%22:%91%22border_color_left%22,%22border_color_left%22%93}\u00a0\u00bb]<\/p>\n
2019<\/p>\n
Dr Martin Schl\u00e4pfer, Privatdozent, et Dr Beatrice Beck-Schimmer, Professeur.<\/p>\n
[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb2_5,3_5″ use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb2″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width_tablet=\u00a0\u00bb100%\u00a0\u00bb width_phone=\u00a0\u00bb100%\u00a0\u00bb width_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb max_width=\u00a0\u00bb1296px\u00a0\u00bb custom_margin=\u00a0\u00bb||||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|true\u00a0\u00bb border_style_all=\u00a0\u00bbnone\u00a0\u00bb border_width_bottom=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom=\u00a0\u00bb#cecece\u00a0\u00bb collapsed=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb2_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/sedanamedical.com\/wp-content\/uploads\/2024\/11\/Dr-Martin.jpg\u00a0\u00bb alt=\u00a0\u00bbDr Martin\u00a0\u00bb title_text=\u00a0\u00bbDr-Martin\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb border_radii=\u00a0\u00bbon|10px|10px|10px|10px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb3_5″ _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.0″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bb–et_global_heading_font||||||||\u00a0\u00bb text_font_size=\u00a0\u00bb18px\u00a0\u00bb text_letter_spacing=\u00a0\u00bb0.05rem\u00a0\u00bb text_line_height=\u00a0\u00bb28px\u00a0\u00bb text_font_size_tablet=\u00a0\u00bb18px\u00a0\u00bb text_font_size_phone=\u00a0\u00bb16px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb text_line_height_tablet=\u00a0\u00bb28px\u00a0\u00bb text_line_height_phone=\u00a0\u00bb26px\u00a0\u00bb text_line_height_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
L’objectif de cet essai est d’\u00e9tudier l’effet d’une s\u00e9dation initiale temporaire au s\u00e9voflurane sur la mortalit\u00e9 et le dysfonctionnement persistant des organes (POD) chez les survivants au 28e jour apr\u00e8s l’admission aux soins intensifs dans la population de patients souffrant d’un SDRA COVID-19.<\/p>\n
La pand\u00e9mie de coronavirus 19 (COVID-19), caus\u00e9e par le coronavirus 2 du syndrome respiratoire aigu s\u00e9v\u00e8re (SARS-CoV-2), se propage rapidement en Europe. Si les donn\u00e9es des centres europ\u00e9ens manquent encore, plusieurs publications de centres chinois sont disponibles. <\/p>\n
L’insuffisance respiratoire due au syndrome de d\u00e9tresse respiratoire aigu\u00eb (SDRA) est la principale cause de mortalit\u00e9 et peut \u00eatre caus\u00e9e ou exacerb\u00e9e par un \u00ab\u00a0syndrome d’orage cytokinique\u00a0\u00bb.<\/p>\n
Des essais r\u00e9cents de notre groupe ont d\u00e9montr\u00e9 que l’anesth\u00e9sique volatil sevoflurane administr\u00e9 pendant la ventilation des patients a des propri\u00e9t\u00e9s anti-inflammatoires. De plus, dans des \u00e9tudes in vivo, les anesth\u00e9siques volatils r\u00e9duisent la gravit\u00e9 du SDRA par rapport \u00e0 la s\u00e9dation intraveineuse, ce qui a \u00e9t\u00e9 confirm\u00e9 dans un essai clinique pilote. L’att\u00e9nuation du SDRA et donc l’am\u00e9lioration de l’oxyg\u00e9nation diminuent fortement la morbidit\u00e9 et la mortalit\u00e9 des patients\u00a0\u00bb. <\/p>\n
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La s\u00e9dation par inhalation aux soins intensifs Accueil Nos recherches Bourse de recherche L’une des missions de Sedana Medical est d’am\u00e9liorer les r\u00e9sultats pour les patients gr\u00e2ce \u00e0 l’innovation m\u00e9dicale. La bourse de recherche m\u00e9dicale Sedana (SMRG), cr\u00e9\u00e9e en 2019, fait partie int\u00e9grante de cette mission. Il s’agit d’une opportunit\u00e9 pour la communaut\u00e9 scientifique d’am\u00e9liorer […]<\/p>\n","protected":false},"author":249802924,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","footnotes":""},"dipi_cpt_category":[],"class_list":["post-5856","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n
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